Aging, Neurodegenerative Diseases, Stress Resistance, Adaptive Evolution
 

 

Sulfate assimilation regulates hydrogen sulfide production independently of lifespan and reactive oxygen species under methionine restriction.

Choi Kyung-Mi, Kim S, Kim SH, Lee HM, Kaya A, Bok-Hwan C, Yong KL, Tae-Sik P, Cheol-Koo L, Seong-il E, Lee BC (2019)

Aging, 11(12): 4254–4273.

 

Population genomics of finless porpoises reveal an incipient cetacean species adapted to freshwater.
Zhou X, Guang X, Sun D, Xu S, Li M, Seim I, Jie W, Yang L, Zhu Q, Xu J, Gao Q, Kaya A, Dou Q, Chen B, Ren W, Li S, Zhou K, Gladyshev VN, Nielsen R, Fang X, Yang G. (2018)
Nat Commun. 9, 1276.

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Cytochrome C peroxidase facilitates the beneficial use of H2O2 in prokaryotes.

Kaya A, Mariotti M, Gladyshev VN (2017)

Proc. Natl. Acad. Sci. USA, (33)8678-8680.

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Age-associated damage contributes to aging and may modulate lifespan through diet.

Lee SG, Kaya A, Avanesov A, Gladyshev VN (2015)

Sci Adv. 2017 Feb 17;3(2):e1601833.

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Methionine restriction and lifespan control.

Lee BC*, Kaya A*, Gladyshev VN (2015)

Ann. NY Acad. Sci. 1363, 116-124. (* Equal contribution)

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Adaptive aneuploidy protects against thiol peroxidase deficiency by increasing respiration via key mitochondrial proteins.

Kaya A, Gerashchenko MV, Labarra J, Toledano M, Gladyshev VN (2015)

Proc. Natl. Acad. Sci. USA, 112, 10685-10690.

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Defining Molecular Basis for Longevity Traits in Natural Yeast Isolates.

Kaya A, Ma S, Wasko B, Lee M, Kaeberlein M, Gladyshev VN (2015)

Npj Aging and Mech. of Disease, doi:10.1038/npjamd.2015.1.

Regulation of protein function by reversible methionine oxidation and the role of selenoprotein MsrB1.

Kaya A, Lee BC, Gladyshev VN (2015)

Antioxid Redox Signal. 23, 814-822.

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Evidence that mutation accumulation does not cause aging in Saccharomyces cerevisiae.

Kaya A, Lobanov AV, Gladyshev VN (2015)

Aging Cell doi: 10.1111/acel.12290.

(selected as Editors’ choice on Science; http://science.sciencemag.org/content/347/6228/twil).

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Thiol peroxidase deficiency leads to increased mutational load and decreased fitness in Saccharomyces cerevisiae.

Kaya A, Lobanov AV, Gerashchenko MV, Koren A, Fomenko DE, Gladyshev VN (2014)

Genetics 198, 905-917.

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Characterization of a cDNA from Beta maritima that confers nickel tolerance in yeast.

Bozdag GO,, Koc A, Noll GA, Prüfer D, Karakaya HC (2014)

Gene, 538, 251-217.

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Methionine restriction extends lifespan of Drosophila melanogaster and Saccharomyces cerevisiae and this effect depends on the low amino acid status.

Lee BC, Kaya A, Ma S, Kim G, Gerashchenko MV, Yim SH, Hu Z, Harshman LG, Gladyshev VN (2013)

Nat Commun. 5, 3592.

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Lifespan extension conferred by endoplasmic reticulum secretory pathway deficiency requires Induction of the unfolded protein response.

Labunskyy VM, Gerashchenko MV, Delaney JR, , Kennedy BK, Kaeberlein M, Gladyshev VN (2013)

PLoS Genetics 10, e1004019.

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MsrB1 and MICALs regulate actin assembly and macrophage function via reversible stereoselective methionine oxidation.

Lee BC, Peterfi Z, Hoffmann FW, Moore RE, Kaya A, Avanesov A, Tarrago L, Zhou Y, Weerapana E, Fomenko DE, Hoffmann PR, Gladyshev VN (2013)

Mol Cell 51:397-404.

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Diversity of plant methionine sulfoxide reductases B and evolution of a form specific for free methionine sulfoxide.

Le DT, Tarrago L, Watanabe Y, Kaya A, Lee BC, Tran U, Nishiyama R, Fomenko DE, Gladyshev VN, Tran LS (2013)

PLoS One 8, e65637.

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Characterization of methionine oxidation and methionine sulfoxide reduction using methionine-rich cysteine-free proteins.

Liang X, Kaya A, Zhang Y, Le DT, Hua D, Gladyshev VN (2012)

BMC Biochem. 23, 13-21.

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Methionine sulfoxide reductases preferentially reduce unfolded oxidized proteins and protect cells from oxidative protein unfolding.

Tarrago L, Kaya A, Weerapana E, Marino SM, Gladyshev VN (2012)

J. Biol. Chem. 287, 24448-24459.

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Boron stress activates the general amino acid control mechanism and inhibits protein synthesis.

Uluisik I, Kaya A, Fomenko DE, Karakaya HC, Carlson BA, Gladyshev VN, Koc A (2011)

PLoS One 6, e27772.

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A 4-selenocysteine, 2-selenocysteine insertion sequence (SECIS) element methionine sulfoxide reductase from Metridium senile reveals a non-catalytic function of selenocysteines.

Lee BC, Lobanov AV, Marino SM, Kaya A, Seravalli J, Hatfield DL, Gladyshev VN (2011)

J. Biol. Chem. 286, 18747-18755.

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Thiol peroxidases mediate specific genome-wide regulation of gene expression in response to hydrogen peroxide.

Fomenko DE, Koc A, Agisheva N, Jacobsen M, Kaya A, Malinouski M, Rutherford JC, Siu KL, Jin DY, Winge DR, Gladyshev VN (2011)

Proc. Natl. Acad. Sci. USA 108, 2729-2734.

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Genome-wide identification of genes that play a role in boron stress response in yeast.

Uluisik I, Kaya A, Unlu ES, Avsar K, Karakaya HC, Yalcin T, Koc A (2011)

Genomics 97, 106-111.

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Compartmentalization and regulation of mitochondrial function by methionine sulfoxide reductases in yeast.

Kaya A, Koc A, Lee BC, Fomenko DE, Rederstorff M, Krol A, Lescure A, Gladyshev VN (2010)

Biochemistry 49, 8618-8625.

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Diversity of protein and mRNA forms of mammalian methionine sulfoxide reductase B1 due to intronization and protein processing.

Liang X, Fomenko DE, Hua D, Kaya A, Gladyshev VN (2010)

PLoS One 5, e11497.

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Identification of a novel system for boron transport: Atr1 is a main boron exporter in yeast.

Kaya A, Karakaya HC, Fomenko DE, Gladyshev VN, Koc A (2009)

Mol. Cell. Biol. 29, 3665-3674.

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Functional analysis of free methionine-R-sulfoxide reductase from Saccharomyces cerevisiae.

Le DT, Lee BC, Marino SM, Zhang Y, Fomenko DE, Kaya A, Hacioglu E, Kwak GH, Koc A, Kim HY, Gladyshev VN (2009)

J. Biol. Chem. 284, 4354-4364.